Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies

This research examines the link between migraine and ischaemic stroke risk. It includes a systematic review and meta-analysis of studies from 1966 to 2004. Fourteen studies were analyzed, consisting of 11 case-control and 3 cohort studies. Findings indicate that people with migraine face a higher stroke risk. The relative risk for stroke in migraine patients is 2.16. This risk remains elevated for those with migraine with aura, at a relative risk of 2.27. Additionally, migraine without aura shows a relative risk of 1.83. Notably, women using oral contraceptives have an even higher risk, with a relative risk of 8.72. Overall, migraine appears to be a significant risk factor for developing stroke. Future research should explore the underlying mechanisms of this association. Further investigation is also needed for migraine risk in those using oral contraceptives. Clinical relevance: This research highlights the increased stroke risk in individuals with migraine, especially among oral contraceptive users.