Migraine and cardiovascular disease: systematic review and meta-analysis

This systematic review and meta-analysis evaluated the link between migraine and cardiovascular disease. Researchers examined stroke, myocardial infarction, and cardiovascular-related death. They included case-control and cohort studies published until January 2009. Studies were assessed by two investigators independently. Disagreements were resolved through consensus. Results showed that migraine significantly increased the risk of ischaemic stroke. The pooled relative risk for ischaemic stroke was 1.73. Those with migraine with aura had a higher risk of 2.16. Women experienced a greater risk of 2.08 compared to men’s 1.37. Factors like age below 45 years, smoking, and oral contraceptive use raised this risk. The study did not find a significant link between migraine and myocardial infarction or cardiovascular death. More studies are needed to understand the impact of modifying factors, such as aura. Overall, the findings suggest important implications for understanding migraine and cardiovascular health. Clinical relevance: This research indicates that migraine with aura significantly increases ischaemic stroke risk, especially in women.