Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Migraine affects about 14% of people globally and is quite debilitating. Its underlying causes remain unclear, sparking debate about vascular versus neuronal dysfunction. Previous studies found 13 loci linked to migraine. In this research, the team analyzed data from 59,674 migraine sufferers and 316,078 controls. They identified 44 significant single-nucleotide polymorphisms associated with migraine risk. These SNPs mapped to 38 distinct genomic loci. Among these, 28 loci were previously unreported. Remarkably, one locus was newly identified on chromosome X. The study's results suggest that the identified loci are enriched for genes found in vascular and smooth muscle tissues. This aligns with theories that emphasize vascular causes of migraines. The findings enhance our understanding of migraine's genetic underpinnings. They could pave the way for new treatments targeting these specific genetic factors. This research represents a significant advancement in migraine genetics and potential future therapies. Clinical relevance: This research could lead to targeted therapies that address the genetic factors influencing migraine.