Hypothalamus as a conductor of the migraine prodrome: A narrative review.

This narrative review discusses the hypothalamus's role in migraine prodrome. Prodrome is the initial phase of a migraine attack. Understanding this phase can help explain migraine initiation. It may also identify treatment targets for acute prevention. Symptoms of the prodrome often localize to the hypothalamus. These include hypersensitivity to light and sound, neck pain, and fatigue. Changes in appetite, mood, and sleep-wake disturbances are common as well. Several neuropeptides and neurotransmitters relevant to migraines are influenced by the hypothalamus. Neuroimaging studies show increased hypothalamic activity during the prodrome phase. This suggests that the hypothalamus plays a significant role in migraine attacks. The review highlights the need for further research in this area. Understanding these mechanisms could lead to better migraine treatments. The hypothalamus's contribution to migraine needs comparison with other brain regions. Overall, this research underscores the hypothalamus's importance in migraine management. Clinical relevance: This research indicates that understanding the hypothalamus's role could lead to improved migraine treatments and potential prevention strategies for those affected by migraines.