Concurrent VVOR and VORS profiling reveals a threshold-dependent VOR suppression deficit in vestibular migraine.

This study examined visual-vestibular integration in vestibular migraine patients. Researchers compared 57 patients with vestibular migraine to 30 healthy controls. They assessed visually enhanced vestibulo-ocular reflex (VVOR) and vestibulo-ocular reflex suppression (VORS). The tests were performed using video-oculography during head rotation. Results showed that patients had higher VVOR gains than controls. Specifically, the mean VVOR gain was 1.4 versus 1.2. Additionally, patients exhibited elevated VORS gains compared to controls. Importantly, VORS showed a significant nonlinear relationship with vestibular migraine risk. The steepest increase in risk occurred between VORS values of 0.39 to 0.60. VORS impairment was identified as a strong indicator of vestibular migraine. This study provides new insights into the mechanisms of vestibular migraine. It suggests that focusing on VORS may improve diagnosis and treatment, highlighting its clinical significance in managing this condition effectively. Clinical relevance: This study highlights the importance of VORS in identifying vestibular migraine, potentially improving diagnosis and treatment outcomes for patients.