The special extract ERr 731^® from the root of rhapontic rhubarb (<i>Rheum rhaponticum</i>): efficacy in headache/migraine and further climacteric complaints in women in the perimenopause.

Menopause triggers neuroendocrine changes and various climacteric symptoms in women. Hormone replacement therapy (HRT) is the standard treatment but has safety concerns. This study explored ERr 731®, a non-hormonal extract from Rheum rhaponticum. Researchers conducted a 12-week randomized controlled trial and a 52-week observational study. One hundred twelve perimenopausal women aged 45-55 participated in this research. Participants either received ERr 731® (4 mg daily) or a placebo. After 52 weeks, all participants received ERr 731® for evaluation. Results showed significant reductions in climacteric complaints in the ERr 731® group versus placebo. Improvements in headache/migraine and paresthesia symptoms were especially notable. Dizziness reduction was significant between groups. Over 90% of participants reported feeling "good" or "very good spirits" at week 52. ERr 731® proved effective for long-term relief and improved overall well-being in perimenopausal women. Clinical relevance: This research suggests that ERr 731® can effectively manage menopausal symptoms in women.