MigraineMind research summary
Real-world outcomes of zavegepant use in a tertiary care setting using the Migraine Treatment Optimization Questionnaire-5.
Headache | 2026
Observational studySummary
The introduction of calcitonin gene-related peptide antagonists has changed migraine treatment. Zavegepant is a third-generation intranasal gepant for acute migraine relief. Although clinical trials show its effectiveness, real-world data are scarce. This study analyzed patient-reported outcomes of zavegepant at a tertiary care center. Researchers used the Migraine Treatment Optimization Questionnaire-5 and additional surveys. Data were collected from patients prescribed 10 mg intranasal zavegepant between July 2023 and December 2024. Surveys were conducted from January 2025 to March 2025. Out of 99 patients surveyed, 60 met inclusion criteria for analysis. Among those, 45% reported pain freedom within 2 hours half the time. After zavegepant use, 63% achieved pain freedom within 2 hours. Additionally, 60% could return to normal activities half the time or more. The study indicates zavegepant may be a helpful acute migraine treatment option. Many patients reported improvements in pain and daily functioning. Clinical relevance: This study shows that zavegepant may effectively relieve acute migraines in practice.
Key Learning Points
- Zavegepant is a new intranasal treatment option that can provide relief for acute migraines.
- In clinical practice, 63% of patients experienced pain freedom within 2 hours of using zavegepant.
- Nearly 60% of patients were able to resume normal activities half the time after using zavegepant.
- Real-world data on zavegepant's effectiveness is still limited, despite promising trial results.
- This study suggests zavegepant may improve both pain levels and daily functioning for migraine sufferers.
Related migraine research topics
Original research
Read the original publication and review its full methods and findings on PubMed.
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