[Transgender health, migraine and headache-Underestimated associations, limited data situation].

Migraine and headache disorders are important in transgender patient care. Gender-affirming hormone therapies cause changes in physiological systems, affecting migraine symptoms. These changes align with the affirmed gender's endocrine profile. Consequently, they can influence migraine frequency, intensity, and triggers. Psychosocial factors are also significant. Transgender individuals face unique stressors impacting pain experience and migraines. The current data on this topic is limited and often unclear. Most studies have small participant groups and lack control. Additionally, definitions of headache disorders vary widely across different studies. This article aims to highlight the difficulties transgender patients face with migraines and headaches. It does not claim to be exhaustive but provides an overview of these challenges. Understanding these associations is crucial for better patient care and treatment outcomes in this population. Achieving comprehensive knowledge will ultimately improve migraine management for transgender individuals. Clinical relevance: This research highlights the need for better migraine management in transgender patients.