Electroacupuncture for Menstrual-Related Migraine: Protocol for a Multicenter Single-Blinded Randomized Controlled Trial.

Menstrual-related migraine (MRM) affects many females, causing severe symptoms and poor treatment responses. This condition significantly impacts their quality of life. Electroacupuncture may provide a nonpharmacological treatment option for MRM. However, there's limited high-quality research on its effectiveness. This study presents a protocol to assess electroacupuncture's therapeutic effects in MRM. A total of 120 participants will be randomly assigned to two groups. One group will receive electroacupuncture, while the other receives sham electroacupuncture. Each participant will undergo 30-minute treatments for six sessions over 12 weeks. The primary outcome will focus on migraine days and attacks during the final weeks compared to the baseline. Secondary outcomes will include various frequency-related and symptom characteristics, along with patient-reported measures like the visual analog scale and other questionnaires. All adverse events will be documented, ensuring comprehensive safety monitoring throughout the study. Clinical relevance: This research aims to evaluate electroacupuncture as a potential treatment for menstrual-related migraine, offering hope for better patient management options.