Migraine phenotypes defined by disability, pain topography and autonomic features: association with serum vitamin D status.

Migraine presents a wide range of symptoms and experiences among patients. This research explored how vitamin D levels relate to different migraine types. The study analyzed 95 patients, collecting data on various migraine characteristics. Researchers identified four distinct migraine phenotypes using cluster analysis techniques. These clusters varied in features like pain lateralization, disability, and autonomic symptoms. Vitamin D levels were examined across these phenotypes, revealing a general deficiency in the population. About 67% of patients had vitamin D levels below 20 ng/mL. Despite the high deficiency rate, vitamin D levels did not significantly differ between the phenotypes. Female patients were more likely to have a severe migraine phenotype. The findings suggest that while vitamin D deficiency is common, it is not specific to migraine. Understanding these phenotypes could help tailor treatments for individuals based on their unique migraine characteristics. Clinical relevance: This research highlights the importance of classifying migraine types for better treatment strategies.