Peripheral Nerve Blocks in Adolescents with Medically Refractory Migraine: A Retrospective Observational Study.

This study evaluated the effectiveness and safety of peripheral nerve blocks in adolescents. Twenty-eight adolescents with refractory migraines were included in the assessment. The greater occipital nerve and lesser occipital nerve blocks were performed over three sessions. These sessions occurred at eight-week intervals. Pain severity was measured using the Visual Analog Scale. The results showed a decrease in monthly migraine frequency from 14.4 to 4.7 days. The mean VAS score also decreased from 7.7 to 3.3. Eighteen patients experienced marked improvement, while six noted partial benefit. Four patients had no response to the treatment. Questionnaire results indicated better pain control and improved daily functioning for patients. Adverse effects were mild and temporary, with no serious complications reported. Overall, peripheral nerve blocks may reduce headache frequency and severity in adolescents with refractory migraines. Larger controlled studies are needed to support these findings. Clinical relevance: This research suggests that peripheral nerve blocks may significantly improve migraine management in adolescents.