Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism and Migraine Susceptibility and Phenotypes: A Clinical-Genetic Study in a United Arab Emirates (UAE) Cohort.

Migraine is a complex disorder with a significant genetic basis. The ACE insertion/deletion polymorphism may influence vascular regulation and neurovascular reactivity. This study aimed to assess its role in migraine susceptibility and clinical expression. Researchers included 183 participants, consisting of 82 migraine patients and 101 controls. Genomic DNA was extracted from blood samples, and ACE I/D genotyping was performed. Overall genotype frequencies showed 44% for Deletion/Deletion, 39% for ID, and 18% for Insertion/Insertion. Genotype distributions were similar between patients and controls. No significant associations were found between ACE I/D polymorphism and migraine susceptibility or subtypes. However, the Insertion/Insertion genotype correlated with higher Migraine Disability Assessment scores. Ultimately, the study concluded that ACE I/D polymorphism does not significantly influence migraine susceptibility in this cohort. These findings emphasize the need for further research into genetic mechanisms affecting migraine. Clinical relevance: This research indicates that ACE I/D polymorphism does not significantly impact migraine susceptibility or clinical expression in patients.