Multimodal retinal imaging in migraine: Structural and vascular correlates of clinical characteristics.

This study evaluated retinal changes in migraine patients using optical coherence tomography. Researchers compared 68 eyes from migraine patients to 68 eyes from controls. The average age of participants was 35.8 years. The study included a higher number of females, with a ratio of 1.83. Among migraine patients, 47% experienced migraine with aura. Researchers found a reduction in upper retinal nerve fiber layer thickness in migraine patients. However, no other significant differences were observed in OCT or OCT-A metrics. They noted correlations between OCT measurements and factors like disease duration, severity, and attack frequency. Interestingly, no correlations were found regarding migraine laterality. Researchers concluded that OCT and OCT-A could be valuable biomarkers. These tools may help diagnose, monitor, and predict outcomes in both aura and non-aura migraines. This could enhance the management of migraine patients in clinical settings. Clinical relevance: This research shows that retinal imaging may improve migraine diagnosis and monitoring.