U.S. Veterans Using Remote Electrical Neuromodulation for Migraine: A Prospective Real-World Evidence Study of Treatment Patterns, Medication Use, Effectiveness, and Safety (2020-2025).

Among U.S. veterans, migraines and headaches are very common. These disorders often co-occur with other health conditions. Thus, effective, well-tolerated, drug-free treatments are essential. Remote electrical neuromodulation (REN) is a wearable device for treating migraines. This study assessed REN's treatment patterns, medication use, effectiveness, and safety. It involved veterans prescribed REN as part of their care. Data was gathered using the REN mobile app, Nerivio. The study included 466 veterans with an average age of 49 years. Veterans completed 28,274 REN treatments. Remarkably, 76.7% of treatments required no rescue medications. Pain relief was achieved by 67% of patients. Additionally, 26% reported freedom from pain. Functional disability relief was reported by 69%, while 56% experienced symptom relief. Only 0.4% of patients reported device-related adverse events. This study demonstrates REN's effectiveness as a safe alternative for treating migraines in veterans. Clinical relevance: This study shows REN as a safe, effective, drug-free option for veterans with migraines.