Expanding the Neurological Phenotype of ZTTK Syndrome: A Case of Recurrent Acute Confusional Migraine.

Acute confusional migraine (ACM) is a rare type of migraine in children. It causes confusion, agitation, and changes in brain activity. This paper discusses a child with ACM and ZTTK syndrome. ZTTK syndrome is a rare condition linked to a gene mutation. Symptoms of ZTTK include developmental delays, intellectual disabilities, and unique facial features. The child also showed brain structure abnormalities. Researchers believe that the SON gene mutation may lead to increased brain activity. This increased activity could make the child more prone to ACM. The study suggests that ACM might be related to this genetic condition. Understanding this link could help doctors better treat children with ACM. More research is needed to explore these connections fully. This case highlights the importance of recognizing ACM in children with complex genetic conditions. Clinical relevance: This research suggests that understanding genetic links in ACM could improve diagnosis and treatment for affected children.