Evaluating the Risk of Ischemic Stroke With Low-Dose Combined Oral Contraceptives in Women With Migraine: A Nationwide Claims Database Study.

Combined oral contraceptives (COCs) are often avoided by women with migraines. This is due to fears of ischemic stroke risk. This study looked at low-dose COCs and stroke risk in women with migraines. Researchers used a large claims database in Japan. They focused on women aged 20-49 diagnosed with migraines. The study included data from April 2012 to March 2024. Women were compared based on their use of COCs with estrogen doses of 20 and 35 μg. The analysis involved over 215,000 women. Out of these, 453 had ischemic strokes during the follow-up period. The study aimed to provide clearer insights on the safety of low-dose COCs. The findings could help women and doctors make better decisions about contraceptive options. Understanding the risk of strokes with these medications is crucial for managing migraine treatment. Clinical relevance: This research indicates that low-dose COCs may be safer for women with migraines, potentially allowing for better contraceptive choices without significantly increasing stroke risk.