Longitudinal Outcomes of Bilateral and Unilateral Proximal Greater Occipital Nerve Pulsed Radiofrequency in Migraine: A Prospective Randomized Controlled Trial.

This study explored the effects of two different treatments for migraines. Researchers compared unilateral and bilateral greater occipital nerve pulsed radiofrequency (GON-PRF) treatments. They included 187 patients in the trial. Patients received either unilateral or bilateral GON-PRF at the C2 level. The study measured how many headache days patients had each month. It also looked at pain severity and medication use. After six months, results showed that both treatment methods reduced headache days significantly. However, the bilateral approach resulted in better outcomes for some patients. This suggests that treating both sides of the neck might be more beneficial. The study highlights the need for more research to understand the best treatment for migraines. Overall, both unilateral and bilateral GON-PRF can help reduce migraine frequency and severity in patients. Clinical relevance: This study indicates that bilateral GON-PRF may provide better migraine relief than unilateral treatment, guiding clinicians in choosing more effective therapies for their patients.