[Mechanism of Tianshu Capsules in treating migraine rats based on gut microbiota].

This study examined how Tianshu Capsules (TS) could help treat migraines in rats. Researchers created a migraine model using nitroglycerin injections in Sprague-Dawley rats. The rats were divided into five groups: control, model, low-dose TS, medium-dose TS, high-dose TS, and an ibuprofen group. They assessed how well TS improved migraine symptoms by observing general conditions and measuring pain thresholds. They also analyzed gene expression related to pain in the trigeminal ganglion. The study measured key substances in the blood that are linked to migraines, such as endothelin-1, calcitonin gene-related peptide, and serotonin. Additionally, researchers examined the gut microbiota of the rats to see how it might affect migraine treatment. The findings suggest that Tianshu Capsules may improve migraine symptoms through changes in gut bacteria and related biological pathways, offering a new approach for migraine relief. Clinical relevance: This research indicates that Tianshu Capsules may offer a new treatment option for migraine patients by targeting gut microbiota and related biological pathways.