Comprehensive evaluation of volumetric and microstructural alterations of corpus callosum in migraine patients and subtypes using diffusion tensor imaging (DTI).

We studied the brain structure of 103 migraine patients and 47 healthy people. We focused on the corpus callosum, which connects the brain's two halves. We used diffusion tensor imaging (DTI) to assess white matter damage. The patients included 50 with aura and 53 without aura. We compared DTI metrics across four groups. We also measured the volume of the corpus callosum and its relationship with DTI results. Clinical features included age, sex, disease duration, attack frequency, and pain levels. Our results showed decreased ADC and RD values in migraine patients, especially those with aura. Interestingly, we found increased FA values in the overall migraine group. These findings suggest that the corpus callosum may be affected in migraine patients. Understanding these changes could help us better understand migraine and develop new treatments for patients. Clinical relevance: This research indicates that changes in the corpus callosum may help identify migraine subtypes, potentially leading to targeted therapies for improved patient outcomes.