Neural Circuit Dysfunctions in Migraine: A Stage-Specific Dynamic Perspective.

Migraine is now seen as a brain disorder with different clinical phases. These phases show how brain circuits change and interact over time. Researchers reviewed studies from 2010 to 2024 to understand this better. They looked at various types of research, including neuroimaging and neuromodulation. Each migraine phase has unique patterns of brain circuit dysfunction. For example, during the interictal phase, the brain shows specific changes. Understanding these changes can help identify how migraines develop and resolve. The research highlights that migraines are not just about pain but involve complex brain processes. This new perspective could lead to better treatments by targeting these brain circuit changes. Overall, the findings suggest that migraines involve a dynamic interplay of neural circuits throughout different stages, which may help improve patient management and therapy options in the future. Clinical relevance: This research highlights that understanding migraine's neural circuits could lead to more effective treatments tailored to individual patients' specific migraine phases.