Peptides whose levels change during the attack period in episodic migraine: NETRIN-1 and amylin.

This study explored the levels of two proteins, netrin-1 and amylin, in migraine patients. Researchers looked at 60 patients with episodic migraine and 30 healthy individuals. They measured these protein levels during migraine attacks and between attacks. The results showed that netrin-1 levels were significantly lower in migraine patients compared to healthy controls. Specifically, migraine patients had an average of 492.7 pg/mL, while healthy individuals had 744.8 pg/mL. Although amylin levels were also lower in migraine patients, this difference was not statistically significant. Researchers did not find any notable differences in protein levels between patients with aura and those without. They also noted no significant changes between the attack and non-attack periods. This research highlights the potential role of neuroinflammation in migraines and suggests that further studies could help understand these protein levels better. Clinical relevance: This study indicates that lower netrin-1 levels in migraine patients may help identify new treatment strategies targeting neuroinflammation.