Vitamin D concentrations and neutrophil-to-lymphocyte ratio are associated with disability and pain sensitivity in individuals with migraine: a cross-sectional study.

This study investigated how certain biological markers relate to migraine symptoms. Researchers studied 72 adults diagnosed with migraines. They looked at factors like pain sensitivity, disability, stress, and muscle strength. They measured vitamin D levels and the neutrophil-to-lymphocyte ratio (NLR) in participants. Results showed that a higher NLR was linked to more migraine-related disability and greater perceived stress. Additionally, higher vitamin D levels were associated with increased pain thresholds, meaning participants experienced less pain. Specifically, this correlation was strongest in the anterior temporalis area of the head. The findings suggest that both vitamin D and NLR could play important roles in understanding migraine severity and related symptoms. This research highlights potential areas for future treatment strategies that could help manage migraines better by addressing these biological factors. Clinical relevance: This research indicates that vitamin D and NLR might influence migraine severity and disability, suggesting new avenues for treatment and management strategies for patients.