Efficacy and Safety of Cannabinoid-Based Interventions for Low Back Pain and Migraine: A Systematic Review of Randomized Controlled Trials.

Cannabinoid-based treatments are being studied for low back pain and migraines. These conditions cause significant disability in many people. Researchers reviewed several clinical trials to assess their effectiveness and safety. They focused on isolated cannabinoids, synthetic forms, and vaporized cannabis products. Five trials with 1,072 participants were included in the review. The studies used rigorous methods to ensure reliability. In cases of acute low back pain, a single dose of 400 mg showed some effectiveness. However, the results were mixed for migraines and other headache disorders. Overall, while cannabinoids show promise, more research is needed to understand their true value for these conditions. Understanding how these treatments work could help improve pain management strategies. Patients and healthcare providers should stay informed about ongoing research in this area. The findings highlight the potential of cannabinoids but also the need for caution. Clinical relevance: This research indicates that cannabinoid-based treatments may offer new options for managing low back pain and migraines, though further studies are necessary to confirm their effectiveness and safety.