Effectiveness of atogepant in migraine with and without medication overuse: Pooled real-world analysis of two independent clinical cohorts.

This study looked at how effective atogepant is for treating migraines. Atogepant is taken once daily at a dose of 60 mg. Researchers combined data from two groups of patients with migraines. One group followed up after 12 weeks, while the other followed up after 3 months. The study included 78 patients in total. They measured how many migraine days patients had each month. They also tracked how much medication patients used for symptom relief. The researchers used specific tests to assess migraine-related disability and headache impact. They wanted to see if medication-overuse headache (MOH) affected how well patients responded to atogepant. This research helps to understand the effectiveness of atogepant in real-world settings, especially for those with treatment-resistant migraines. The findings could guide future treatment strategies for patients struggling with migraines and MOH. Clinical relevance: This study indicates that atogepant may effectively reduce migraine days, even in patients with medication-overuse headache.