Omega-3 Supplementation with Lipid Biomarker Assessment in Youth with Migraine: A Quasi-Randomized Controlled Feasibility Trial.

This study explored whether omega-3 supplements could help young people with migraines. Researchers focused on children and teens aged 10 to 17 years. They conducted a trial at two pediatric neurology clinics. Participants received either omega-3 supplements or a coconut oil placebo for 12 weeks. The team aimed to assess how feasible it was to conduct this trial. They looked at recruitment success, participant retention, and how well caregivers reported supplement adherence. They also collected blood samples to measure specific lipid biomarkers. The study found that integrating nutrition-based interventions in migraine treatment is possible. It highlighted the importance of measuring biological responses alongside patient-reported outcomes. Overall, the trial aimed to understand if omega-3s could influence migraine symptoms in youth. Results could inform future studies and treatments in pediatric migraine care. Clinical relevance: This research suggests that omega-3 supplementation may offer a new approach to managing migraines in youth, potentially improving treatment outcomes for this population.