New insights into understanding Xiongzhi Qufeng Zhitong Granule's anti-migraine effects and mechanism on reserpine-induced mice: from network pharmacology, molecular dynamics simulation, and experimental validation.

Xiongzhi Qufeng Zhitong Granule (XZQF) is a traditional Chinese medicine for migraines. This study investigates how XZQF helps reduce migraine symptoms in mice. Researchers used a model where migraines were triggered by reserpine. They focused on the 5-HT1B/TPH2/CGRP signaling pathway. This pathway is important in understanding migraine mechanisms. The study found that XZQF significantly improved behavioral symptoms in the mice. It also increased pain thresholds, suggesting effective pain relief. Researchers measured serum and tissue changes to understand XZQF's effects better. The findings support the idea that XZQF has a strong anti-migraine effect. This research is essential for optimizing XZQF's clinical use. It could lead to better treatments for migraine sufferers. Understanding its mechanisms helps clarify how traditional medicines work in modern contexts. Overall, this study provides valuable insights into migraine treatment using traditional remedies. Clinical relevance: This research highlights XZQF's potential to enhance migraine treatment, offering new therapeutic options for patients.