Natural (+)-Camphor Alleviates Migraine Induced by Reserpine with Local Cerebral Vasospasm via Inhibiting p38β MAPK/ATF2 Pathway.

Natural (+)-camphor (NC) is a compound found in traditional Chinese medicine. This study explored its effects on migraines induced by reserpine in mice. Researchers used a model that mimics migraine characteristics. They analyzed brain proteins to understand how NC works. The study found that migraine mice had lower pain thresholds and severe brain damage. They also showed reduced nitric oxide levels in their blood. When treated with NC, the mice showed improvements in their condition. The researchers identified 479 proteins that changed in response to NC treatment. This suggests that NC helps alleviate migraines by influencing specific biological pathways. The findings link traditional herbal medicine to modern migraine research. They highlight the potential for NC as a treatment option. Overall, this study opens doors for new migraine therapies based on traditional practices. Clinical relevance: This research suggests that natural (+)-camphor may offer a new treatment option for migraine sufferers, potentially improving outcomes through its effects on specific biological pathways.