A Review of the Vascular Pathophysiology of Migraine: Should We Consider Statins as a Treatment Option?

Migraine is a common headache disorder affecting over a billion people globally. It can significantly reduce quality of life for those who suffer from it. Researchers believe inflammation and blood vessel dysfunction contribute to migraine development. Statins are medications primarily used to lower cholesterol levels. However, they also have additional benefits, such as reducing inflammation and improving blood vessel function. This review examines whether statins could help prevent migraines and related vascular issues. The authors conducted a literature search for studies published from 1997 to June 2026. They found that most studies support using statins for migraine management. Many patients experienced fewer migraines and better cardiovascular health while on statin therapy. This suggests that statins might play a role in treating migraines. Overall, the findings indicate a potential new approach to managing this debilitating condition effectively. Clinical relevance: This research suggests that statins may offer new treatment options for migraine sufferers, improving their overall health and quality of life.