Migraine and Obesity: From Shared Mechanisms to Therapeutic Strategies.

Migraine and obesity are common, long-lasting conditions that often occur together. Their connection is complex and works both ways. Research shows obesity likely contributes to migraine more than the reverse. This relationship is driven by shared biological factors. These include low-grade inflammation and metabolic issues like insulin resistance. These problems affect brain regulation and neuropeptide signaling, especially involving calcitonin gene-related peptide (CGRP). This leads to increased migraine attacks and chronic pain. People with excess weight often experience more frequent and intense migraines. This is particularly true for women of reproductive age. Additionally, migraines can lead to weight gain due to related psychological issues. Understanding this link can help in managing both conditions more effectively. Addressing obesity may reduce migraine frequency and severity, improving quality of life for patients. Clinical relevance: This research highlights the need to address obesity in migraine treatment plans.