Structural alterations in the superior temporal gyrus associated with depressive symptoms in migraine without aura: a voxel-based morphometry and surface-based morphometry magnetic resonance imaging study.

Migraine without aura (MwoA) often occurs alongside depressive symptoms. This study looked at brain structure differences between MwoA patients and healthy controls. It used advanced MRI techniques to analyze gray matter and cortical features. A total of 67 MwoA patients participated, divided into two groups based on depression severity. One group had lower depressive symptoms, while the other had higher symptoms. Researchers measured brain volume and structure to see how they related to depression levels. They found that the brain's superior temporal gyrus showed structural changes linked to depressive symptoms. These findings suggest that MwoA and depression may share certain brain alterations. Understanding these changes could help in treating both conditions more effectively. This research highlights the importance of looking at brain structure when considering migraine and depression together. Clinical relevance: This study indicates that structural brain changes in migraine patients may inform treatment strategies for managing both migraine and depressive symptoms.