Acupuncture-Associated Changes in Migraine-Like Behaviors and Serum Proteomic and Metabolomic Profiles in Nitroglycerin-Induced Rats.

Acupuncture is a popular treatment for migraines, but how it works is unclear. This study explored how acupuncture affects migraine symptoms in rats. Researchers used 32 male rats and divided them into four groups. One group received acupuncture, while others did not. They induced migraines in the rats using nitroglycerin. The researchers measured pain responses in the rats' faces and paws. They also collected blood samples to analyze changes in proteins and metabolites. The results showed that acupuncture could change pain responses and biochemical markers related to migraines. This suggests acupuncture may have a biological basis for its effects on migraine. The study provides insights into the potential mechanisms behind acupuncture's benefits for migraine sufferers. Understanding these effects could help improve treatment options for people experiencing migraines in the future. Clinical relevance: This research indicates acupuncture may effectively reduce migraine symptoms through biological changes.