Alterations in the interstitial microenvironment across headache phases and clinical phenotypes in migraine: A multimodal diffusion MRI study.

Migraine is a complex condition that involves changes in the brain's fluid environment. Researchers studied 120 migraine patients and 52 healthy individuals using advanced MRI techniques. They focused on how fluids move around brain structures during different migraine phases. Participants were divided into groups based on their migraine type: episodic migraine (93 patients) and chronic migraine with medication overuse (25 patients). They also looked at whether patients had headaches during their migraines or were headache-free. The study aimed to understand how these changes in the brain might relate to migraine symptoms. They measured the diffusion of fluids in the brain's perivascular spaces, which could help explain why some people experience migraines more severely than others. This research may lead to better understanding and treatment options for migraine sufferers in the future. Clinical relevance: This study highlights the importance of brain fluid dynamics in migraines, suggesting potential new treatment strategies targeting these mechanisms.