Advanced Brain Ageing Associated with Migraine and Post-Traumatic Headache: A Deep Learning Study.

This study explored how brain ageing relates to migraine and post-traumatic headaches. Researchers used deep learning techniques to estimate "brain age" from MRI scans. They looked at the difference between actual age and brain age. This difference may indicate structural changes in the brain. The study focused on various headache types, including migraine and post-traumatic headaches. They trained a predictive model using data from healthy individuals aged 8 to 95 years. This model was more effective than previous methods. They then applied it to a dataset that included healthy controls and headache patients. The main goal was to see how brain age differences linked to headache types. Results showed that those with migraines or post-traumatic headaches had altered brain ages. Understanding these connections can help improve treatment options for people suffering from these headaches. Clinical relevance: This research highlights how brain ageing may influence migraine and headache persistence, potentially guiding better treatment strategies for patients experiencing these conditions.