The glymphatic system as a mechanistic bridge between migraine and sleep: Evidence from clinical studies and animal models.

Migraine is a common and disabling condition that often disrupts sleep. Researchers are exploring how sleep problems relate to migraine susceptibility. The glymphatic system might explain this connection. This system helps clear waste from the brain during sleep. It uses a network that relies on a protein called AQP4. Studies show that disruptions in this system can affect migraine mechanisms. They include changes in blood flow and certain proteins linked to pain. Evidence from brain imaging and animal studies supports these ideas. While findings vary, they suggest that the glymphatic system plays a role in migraines. Understanding this link could lead to better treatments for migraine sufferers. By focusing on sleep and brain waste clearance, we may find new ways to reduce migraine attacks. More research is needed to confirm these findings and their implications for treatment. Clinical relevance: This research highlights the glymphatic system's potential role in migraine and sleep, suggesting new treatment strategies targeting sleep and brain waste clearance may benefit migraine patients.