The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.

Migraine is often linked to pathways in the brainstem and cortex. However, the cerebellum may also play a role in this condition. This review examines various studies about the cerebellum and migraines. It includes anatomical, imaging, and clinical evidence. Research shows that the cerebellum is involved in processing pain signals. Imaging studies indicate changes in cerebellar connectivity during migraine attacks. However, these studies often involve small groups of people. The findings on cerebellar structure vary depending on the analysis methods used. Population studies do not consistently show a general cerebellar deficit in migraines. More specific evidence shows that trigeminal stimulation activates certain cerebellar areas. Vestibular migraines seem to engage broader vestibular networks, including the cerebellum. Treatment-related imaging also reveals changes in the cerebellum, but the exact mechanisms remain unclear. Overall, the cerebellum's role in migraines deserves more attention in research. Clinical relevance: Understanding the cerebellum's involvement in migraines could lead to better-targeted treatments for patients.