Gray and white matter structural alterations in migraine with and without aura: A multimodal MRI and JuSpace analysis.

This research studied brain structure differences in migraine patients. It focused on two types of migraines: with aura (MwA) and without aura (MwoA). The study compared these groups to healthy controls. Researchers used advanced MRI techniques to look at gray and white matter in the brain. Previous studies showed abnormalities in migraine patients, but results varied widely. This study aimed to clarify whether MwA and MwoA have unique structural features. It also explored how these brain changes relate to underlying biological factors. The research involved 30 healthy participants and 40 migraine patients. Participants were recruited from a hospital in Dalian, China, between August 2025 and March 2026. Overall, the study seeks to better understand brain changes in migraine patients and their potential biological significance. Understanding these differences could help improve treatment options for migraine sufferers. Clinical relevance: This study highlights distinct brain structure changes in different migraine types, which may inform future targeted treatments for patients.