An observational, cross-sectional study evaluating the humanistic and economic burden of migraine with comorbid depression across France, Germany, Italy, Spain, the UK, Brazil, and South Korea using the National Health and Wellness Survey.

Migraine is a painful condition that often occurs with depression. This study looked at how migraine and depression affect people's lives in several countries. Researchers gathered data from adults in France, Germany, Italy, Spain, the UK, Brazil, and South Korea. They analyzed health-related quality of life, work productivity, and healthcare costs. The study found that about 36% of people with migraines also had depression. This was similar across different regions. Those with both conditions experienced more difficulties in daily activities and work. They also faced higher healthcare costs. The findings suggest that migraine and depression together create a significant burden. Understanding this connection can help improve treatment and support for patients. Overall, the study highlights the importance of addressing both migraine and depression for better health outcomes. Clinical relevance: This research highlights the need for integrated care for migraine and depression, improving patient outcomes through better treatment strategies.