Research advances on the role of glutamate AMPA receptors in the pathogenesis and treatment of migraine: A narrative review.

Migraine is a common neurological disorder with unclear causes. Recent research highlights the role of glutamate and its AMPA receptors in migraines. Glutamate is the brain's main excitatory neurotransmitter. The study reviewed evidence on how AMPA receptors contribute to migraine development. It also explored the potential of AMPA receptor antagonists as treatment options. Researchers conducted a literature search on PubMed with specific keywords. They included terms like "migraine," "glutamate," and "AMPA receptor." The goal was to find studies that explain the mechanisms behind migraines. They focused on articles published in English until 2025. The findings suggest that targeting AMPA receptors could lead to new migraine treatments. Overall, this research enhances our understanding of migraine biology and treatment options. It may help in developing more effective therapies for those suffering from migraines. Clinical relevance: This research indicates that targeting AMPA receptors could improve migraine treatment options for patients.