Clinical Phenotypes, Neuroimaging, and Outcomes in Prolonged and Persistent Non-Motor Migraine Aura: A Systematic Review and Episode-Level Synthesis.

Prolonged and persistent migraine aura can resemble a stroke but is different. This study reviewed cases lasting over 60 minutes without any brain damage. Researchers followed strict guidelines to gather data from various sources. They searched multiple databases and included only relevant reports. The review focused on individual episodes and their related brain scans. A total of 48 studies were analyzed, covering 80 episodes in 79 patients. Among these, 49 episodes were prolonged, while 31 were persistent. Visual aura was the most common symptom reported. The findings showed a need for better understanding of these conditions. More research is necessary to clarify the clinical features and neuroimaging results. This could help differentiate between migraine aura and other serious conditions. Improved knowledge could lead to better diagnosis and treatment for those affected by prolonged and persistent migraine aura. Clinical relevance: Understanding prolonged and persistent migraine aura can improve diagnosis and treatment strategies for patients experiencing these symptoms.