Migraine-related differences in connectivity patterns during emotional audiovisual processing revealed by functional connectivity multivariate pattern analysis.

Migraine is a complex condition that causes recurrent headaches and various symptoms. These symptoms include sensory, cognitive, autonomic, and emotional changes. People with migraines often have altered processing of visual and auditory information. They may also be more sensitive to sensory stimuli, both during and between attacks. This study explored how migraines affect brain connectivity during emotional audiovisual processing. Researchers used functional magnetic resonance imaging (fMRI) to collect data from 22 individuals with migraines and 21 healthy controls. Participants viewed three types of films: one with negative emotions, one with positive emotions, and one neutral. The study used functional connectivity multivariate pattern analysis to identify unique connectivity patterns in migraine sufferers. These patterns were different from those in healthy individuals. This research provides insights into how migraines influence emotional processing and brain network interactions, which may help develop better treatments in the future. Clinical relevance: This study highlights how migraine affects emotional processing, potentially guiding targeted therapies for improving patient outcomes.