Research progress on the mechanism of microglia-astrocyte signal crosstalk in central sensitization of vestibular migraine.

Vestibular migraine (VM) causes severe vertigo, headaches, nausea, and vomiting. These symptoms significantly impact patients' quality of life. Researchers are still trying to understand how VM develops. Current studies focus on ion channel issues and genetic factors. New evidence shows that neuroinflammation and central sensitization are crucial in VM. Microglia and astrocytes are two important cells in the brain. They help regulate central sensitization through their interactions. The communication between microglia and astrocytes is vital for understanding neuroimmune responses. This review looks at how these cells work together in VM. By summarizing recent studies, the authors aim to shed light on VM's underlying mechanisms. Understanding these processes may help develop better treatments. Researchers hope to find ways to prevent VM episodes and improve patient care. This research could lead to more effective therapies for those suffering from vestibular migraine. Clinical relevance: This research highlights the role of immune cells in vestibular migraine, suggesting potential new treatment strategies targeting neuroinflammation and central sensitization.