Migraine: translational challenges, novel therapies and disease modification.

Migraine is a common neurological disorder affecting many people worldwide. It causes significant disability, especially after stroke. Understanding migraine is complicated due to its biological complexities and varied symptoms. This research reviews current knowledge about migraine mechanisms and treatment options. It discusses what we have learned from previous research, both successful and unsuccessful. The paper highlights recent drug therapies and their effectiveness in real-world situations. It also emphasizes the importance of shifting focus towards long-term management of migraines. Addressing other related health issues, or comorbidities, is crucial for better outcomes. Lastly, the authors suggest adopting a biopsychosocial approach to understand and treat migraines. This approach considers biological, psychological, and social factors that influence pain. Overall, the findings aim to improve migraine treatment and patient quality of life. Clinical relevance: This research highlights the need for comprehensive migraine management strategies that consider multiple factors.