Acupuncture: A Molecular Approach to Migraine Relief

Research Summary

A new study published in the Journal of Molecular Neuroscience uncovers how acupuncture alleviates migraine symptoms at the molecular level. Researchers focused on the role of microRNAs (miRNAs) in this process, revealing that acupuncture significantly upregulates hsa-miR-550a-3-5p in migraine patients. This miRNA targets and inhibits PECAM1, a molecule involved in inflammatory cell migration. By reducing PECAM1 expression, acupuncture effectively decreases the migration of monocytes-macrophages and the secretion of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. These findings highlight acupuncture's potential in modulating inflammation and suggest a new precision treatment target for migraines.

Study Details

📄 Title: Acupuncture Upregulates hsa-miR-550a-3-5p Targeting PECAM1 To Reduce Transendothelial Migration of Inflammatory Cells and Alleviate Migraine.

👥 Research Team: Wu Z et al.

📚 Published In: J Mol Neurosci

📅 Publication Date: 2025 Dec 22

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.