Acupuncture's Molecular Impact: A New Hope for Migraine Relief

Research Summary

A recent study published in the Journal of Molecular Neuroscience uncovers how acupuncture may alleviate migraines at the molecular level. Researchers found that acupuncture significantly upregulates hsa-miR-550a-3-5p in migraine patients, targeting and inhibiting the expression of platelet and endothelial cell adhesion molecule 1 (PECAM1). This inhibition reduces the migration of inflammatory cells and lowers pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6. The study used various assays and a nitroglycerin-induced migraine mouse model to confirm these effects. These findings not only support acupuncture's effectiveness but also suggest new miRNA-based precision treatment strategies for migraines.

Study Details

📄 Title: Acupuncture Upregulates hsa-miR-550a-3-5p Targeting PECAM1 To Reduce Transendothelial Migration of Inflammatory Cells and Alleviate Migraine.

👥 Research Team: Wu Z et al.

📚 Published In: J Mol Neurosci

📅 Publication Date: 2025 Dec 22

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.