BAFF and APRIL: Key Immune Players in Migraine Phases
- MigraineMind
- Dec 6, 2025
- 1 min read
Research Summary
A recent study published in the Journal of Neuroimmunology explored the roles of B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) in migraines. Researchers analyzed blood samples from migraine patients and healthy controls to understand how these proteins, crucial for B-cell regulation, behave across migraine phases. Results showed that BAFF levels significantly increased during migraine attacks (ictal phase) and decreased afterward, while APRIL levels consistently remained lower than those in healthy individuals. These findings suggest a unique immune signature involving B-cells in migraines, highlighting the need for further research into the BAFF-APRIL pathway's role in migraine pathogenesis.
Study Details
👥 Research Team: Smithi N et al.
📚 Published In: J Neuroimmunol
📅 Publication Date: 2025 Nov 30
⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.