CGRP and Piezo1 Interaction: New Insights into Migraines

Research Summary

A recent study published in the journal Cephalalgia explores the intriguing interaction between two molecular pathways implicated in migraines: the calcitonin gene-related peptide (CGRP) and mechanosensitive Piezo1 channels in human endothelial cells. Researchers used human induced pluripotent stem cell-derived endothelial cells (hiPSC-ECs) to investigate this crosstalk. They found that pre-exposure to CGRP increased intracellular calcium levels when subsequently treated with a Piezo1 agonist, Yoda1, compared to simultaneous or separate applications. Furthermore, CGRP receptor blockade reduced calcium levels, confirming pathway interaction. The study also showed that CGRP and Piezo1 activation influenced cellular remodeling, highlighting potential for in vitro migraine vascular research.

Study Details

📄 Title: Indirect crosstalk between signalling pathways activated by CGRP and Piezo1 in human iPSC-derived endothelial cells relevant to migraine.

👥 Research Team: Gkouzioti V et al.

📚 Published In: Cephalalgia

📅 Publication Date: 2025 Dec

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.