CXCL10's Role in Vestibular Migraine: New Pathway Insights

Research Summary

A recent study published in CNS Neuroscience & Therapeutics explores the involvement of the chemokine CXCL10 in vestibular migraine (VM) through the PI3K/AKT signaling pathway. The research highlights a significant correlation between elevated serum CXCL10 levels and the severity of dizziness and headaches in VM patients. In a rat model, increased expression of CXCL10, its receptor CXCR3, and PI3K/AKT signaling molecules were observed in areas of the brain associated with VM. These findings suggest that CXCL10 may contribute to VM pathogenesis by activating the PI3K/AKT pathway and promoting the release of inflammatory factors such as interleukin-1β, interleukin-6, and tumor necrosis factor-α.

Study Details

📄 Title: CXCL10 Involvement in Vestibular Migraine via the PI3K/AKT Signaling Pathway.

👥 Research Team: Song MM et al.

📚 Published In: CNS Neurosci Ther

📅 Publication Date: 2025 Nov

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.