Elevated CGRP Levels in Young Migraine Sufferers Revealed

Research Summary

A new systematic review and meta-analysis published in the European Journal of Pain investigates calcitonin gene-related peptide (CGRP) levels in children and adolescents with migraine. The study analyzed data from eight observational studies and found moderate evidence of significantly elevated CGRP levels in young migraine sufferers compared to non-migraine controls. Specifically, CGRP levels were higher during both ictal and interictal phases. The findings suggest CGRP may be a potential diagnostic biomarker and prophylactic therapeutic target for pediatric migraine. However, the authors emphasize the need for high-quality longitudinal studies to confirm these results and explore the diagnostic value of CGRP further.

Study Details

📄 Title: Calcitonin Gene-Related Peptide (CGRP) Levels of Children and Adolescents With Migraine: A Systematic Review and Meta-Analysis of Observational Studies.

👥 Research Team: Zhu G et al.

📚 Published In: Eur J Pain

📅 Publication Date: 2026 Jan

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.