Epigenetics in Migraines: Unlocking New Treatment Paths

Research Summary

A study published in The Journal of Headache and Pain explores the emerging role of epigenetics in migraines, particularly in treatment-resistant cases. Despite advances in migraine therapies targeting calcitonin-gene related peptide (CGRP) signaling, 40% of patients remain challenging to treat. Researchers are investigating how environmental factors and epigenetic changes, like DNA methylation, impact migraine progression and treatment response. Altered methylation affects genes linked to synaptic plasticity and estrogen signaling, while microRNAs may serve as biomarkers for therapy outcomes. Understanding these mechanisms could enhance personalized treatment strategies, improving efficacy and safety in managing migraines.

Study Details

📄 Title: Epigenetics in migraine: the junior editorial board members' vision.

👥 Research Team: Scuteri D et al.

📚 Published In: J Headache Pain

📅 Publication Date: 2025 Dec 5

⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.