Flunarizine Formulations: Safe Alternatives for Migraine Relief

Research Summary

A recent study published in Drugs in Research and Development explored the bioequivalence of two flunarizine hydrochloride capsule formulations, commonly used for migraine prevention and vertigo management, in healthy Chinese subjects. The research confirmed that both the test and reference formulations were bioequivalent under fasting and fed conditions. This means that they have similar absorption and effect in the body, making the test formulation a viable alternative to the marketed version. Interestingly, high-fat meals delayed drug absorption and increased exposure by 20%. Both formulations were well tolerated without serious side effects, highlighting their safety and potential for broader clinical use.

Study Details

📄 Title: Bioequivalence Study of Two Formulations of Flunarizine Hydrochloride Capsules in Healthy Chinese Subjects Under Fasting and Fed Conditions.

👥 Research Team: Yang Y et al.

📚 Published In: Drugs R D

📅 Publication Date: 2025 Aug 22

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⚕️ Medical Disclaimer: This summary is generated automatically from recent migraine research. Always consult with healthcare professionals for medical advice.